After a week away vs Rutgers and an important game the next game vs Pittsburgh, WVU will play at home vs Louisville on November 5th. These two teams first played against each other in 1984. WVU leads the series 10-2 with the most recent game coming last year with the Mountaineers winning 17-10. This is the 8th game of the season for WVU.

Complete List of Historical Scores for West Virginia vs. Louisville
| Year |
Score |
| 2010 |
W 17-10 |
| 2009 |
W 17-9 |
| 2008 |
W 35-21 |
| 2007 |
W 38-31 |
| 2006 |
L 34-44 |
| 2005 |
W 46-44 |
| 1993 |
W 36-34 |
| 1990 |
L 7-9 |
| 1989 |
W 30-21 |
| 1986 |
W 42-19 |
| 1985 |
W 52-13 |
| 1984 |
W 30-6 |
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